Paternal prepubertal passive smoke exposure is related to impaired lung function trajectories from childhood to middle age in their offspring

J Liu; JL Perret; CJ Lodge; D Vicendese; G Bowatte; AJ Lowe; NS Idrose; P Frith; R Wood-Baker; GD Mishra; JW Holloway; C Svanes; MJ Abramson; EH Walters; SC Dharmage; DS Bui

Journal article

Paternal prepubertal passive smoke exposure is related to impaired lung function trajectories from childhood to middle age in their offspring

J Liu, JL Perret, CJ Lodge, D Vicendese, G Bowatte, AJ Lowe, NS Idrose, P Frith, R Wood-Baker, GD Mishra, JW Holloway, C Svanes, MJ Abramson, EH Walters, SC Dharmage, DS Bui

Thorax | Published : 2026

DOI: 10.1136/thorax-2024-222482

Abstract

Introduction Paternal prepubertal passive smoke exposure may increase the risk of childhood asthma. However, its association with impaired lung function trajectories at risk of chronic obstructive pulmonary disease in offspring was not investigated. We assessed the association between paternal prepubertal passive smoke exposure and lung function from childhood to middle age in their offspring. Methods Data were analysed from 890 father-offspring pairs from the Tasmanian Longitudinal Health Study. The offspring were probands in the original cohort who underwent spirometry at six time points from ages 7 to 53 years. Lung function (forced expiratory volume in 1 s (FEV1), forced vital capacity (..

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University of Melbourne Researchers

Jennifer Perret Author

Caroline Lodge Author

Don Vicendese Author

Gayan Bowatte Author

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Keywords

Respiratory

Copd Epidemiology

Pediatric Research Initiative

3201 Cardiovascular Medicine and Haematology

Tobacco and the Lung

2.1 Biological and Endogenous Factors

Health Effects of Indoor Air Pollution

Tobacco Smoke and Health

Tobacco

Asthma

Prevention

3202 Clinical Sciences

Chronic Obstructive Pulmonary Disease

32 Biomedical and Clinical Sciences